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The Risks of Mixing Cyclobenzaprine and Alcohol—Everything You Need To Know

The Risks of Mixing Cyclobenzaprine and Alcohol—Everything You Need To Know

Imagine lying in bed and staring at the ceiling, your mind racing with the events of the day and your muscles tensed up in discomfort. This nightly struggle with persistent insomnia can leave you exhausted and frustrated. 

After trying various remedies with little success, your doctor may prescribe cyclobenzaprine, especially if your sleep problems are a result of muscle tension and stiffness. Known primarily as a muscle relaxant, cyclobenzaprine works by easing the knots and spasms that keep you awake, paving the way for more restful and rejuvenating sleep.

If your doctor has recommended cyclobenzaprine for your sleep issues, you might wonder—can you drink alcohol while taking cyclobenzaprine? In this article, we’ll explore how cyclobenzaprine and alcohol interact to help you take the necessary precautions when taking the drug.

Can You Drink Alcohol With Cyclobenzaprine?

Doctors advise against drinking alcohol while taking cyclobenzaprine. Alcohol can increase the nervous system side effects of cyclobenzaprine, such as:

  • Dizziness
  • Drowsiness
  • Difficulty concentrating
  • Impairment in thinking and judgment

This combination can significantly impair your ability to perform potentially dangerous activities that require sharp focus, like operating machinery or driving. Additionally, because of alcohol’s potential for abuse, taking cyclobenzaprine concurrently with alcohol over an extended period increases the risk of addiction. To reduce these risks, avoid drinking alcohol while you’re being treated with cyclobenzaprine.

How Long Should You Wait To Drink Alcohol After Taking Cyclobenzaprine?

The time you should wait before drinking alcohol after taking cyclobenzaprine can vary based on several factors, such as:

  • The dosage of cyclobenzaprine taken
  • Your body’s metabolism
  • Your overall health

Typically, cyclobenzaprine has a half-life of about 18 hours, which means it takes approximately 18 hours for half of the dose to be eliminated from your body. Keep in mind that it can take several half-lives for the drug to leave your system completely.

A general guideline is to wait at least 48 hours after your last dose of cyclobenzaprine before consuming alcohol. This allows the medication to get eliminated from your system, reducing the risk of interaction. Since individual factors can influence how long the drug stays in your body, it’s always best to consult your healthcare provider for personalized advice.

What Are the Risks of Taking Cyclobenzaprine With Alcohol?

Combining cyclobenzaprine and alcohol can have severe and potentially dangerous consequences. Both these substances act as central nervous system depressants, and taking them together can lead to an enhanced depressant effect that may affect various bodily functions. Here are some key risks associated with this combination:



Respiratory depression

The combination of these substances can suppress the respiratory system and slow down breathing. This respiratory depression can be life-threatening, especially in cases of overdose

Increased sedation

Cyclobenzaprine can cause drowsiness and sedation. Combining it with alcohol can intensify these effects, leading to excessive sedation, dizziness,  confusion, and impaired coordination

Risk of overdose

The combined use of these substances can increase the risk of overdose. Symptoms of overdose might include severe drowsiness and slow or difficult breathing, especially if taken in large quantities or with other CNS depressants

Increased risk of addiction and abuse

These substances have the potential for misuse and addiction, especially when used inappropriately. Using them together can create a cycle of misuse, increasing the risk of addiction

Source: Kinga Howard

The risks associated with combining alcohol and cyclobenzaprine can increase with higher doses of the medication. For example, taking 10 mg of cyclobenzaprine and alcohol can amplify side effects and increase the risk of complications such as respiratory depression or other central nervous system effects.

How Does Cyclobenzaprine Work?

Cyclobenzaprine is a central nervous system (CNS) depressant that primarily functions as a muscle relaxant. It works by blocking the nerve impulses or pain signals the muscles send to the brain, effectively reducing muscle spasms without impacting the muscle itself. This decreases muscle stiffness, helping alleviate pain and discomfort associated with muscle injuries, spasms, or conditions like fibromyalgia. As your muscles relax, your body is more able to achieve a state of calmness, reducing restlessness and promoting restful sleep.

While cyclobenzaprine is highly effective in treating muscle-related disorders, it should be used under close medical supervision due to the drug’s potential side effects and interactions with other medications. Cyclobenzaprine’s time of action is 4–6 hours, and you should typically take it up to three times a day with or without food. The table below highlights key information about this drug:



Generic name


Brand names

Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril

Drug class

Skeletal muscle relaxants




Muscle relaxant—blocks nerve impulses to the brain


Treats skeletal muscle conditions (pain, injury)


5 mg, 10 mg, 15 mg, and 30 mg

Drug interactions

Risk of serotonin syndrome with certain medications (such as stimulants, opioids, herbal products, or antidepressants)

Dosage forms available

Oral capsule/tablet

Side effects


Suitable for pregnant women

Category B (no proven risk in pregnancy)

Source: Ivan Oboleninov

The Safest Way To Use Cyclobenzaprine for Sleep

Although cyclobenzaprine doesn’t directly target sleep disorders, its primary function as a muscle relaxant can help improve sleep quality by alleviating muscle spasms and associated pain.

Despite its benefits for addressing sleep issues, you should use cyclobenzaprine under the guidance of a healthcare professional—particularly one specializing in sleep medicine. However, specialists in this field are extremely rare in the U.S., with only about 1% of doctors specializing in sleep medicine. This scarcity underscores the value of online performance medicine clinics like Kick, which provide easy access to expert advice and personalized solutions for sleep-related issues.

Kick—A Perfect Solution for Your Sleep Needs

Sleep medications can be a crucial aid if you’re struggling with sleep disorders, offering relief and improving your overall sleep quality. Using these drugs under professional guidance ensures the safety and effectiveness of your treatment—and Kick offers the best expert help for sleep-related issues. Kick’s sleep program is designed by a renowned Stanford sleep specialist, so you’re guaranteed top-notch services, including:

  1. Quick process without the need for in-person doctor visits
  2. Immediate prescription of two trial medications
  3. Personalized treatment based on your specific case
  4. Supervised and adjustable treatment
  5. Access to expert tips on healthy sleep practices
  6. Convenient medication delivery system

That's not all—you can explore Kick with confidence thanks to our Doctor Guarantee policy. If our sleep doctor concludes that Kick’s sleep program isn’t the ideal match for your needs, you won’t be charged for the initial consultation.

Get Started With Kick Today

Source: Andrea Piacquadio

Reclaim your restful nights by following the following easy steps:

  1. Go to Kick’s signup page to initiate your sleep visit
  2. Fill out the questionnaire to provide us with relevant info regarding your specific issue and medical history
  3. Share your shipping address and payment information

Kick has positively transformed numerous lives, which is reflected in our exceptional reviews on Trustpilot. If you're looking to experience a similar change, sign up for Kick and start celebrating your mornings in a whole new way!

Other Cyclobenzaprine Interactions To Consider

When taking cyclobenzaprine, it’s important to be aware of various drug interactions that could potentially lead to adverse effects or reduced effectiveness of the medication. Here are some key interactions to consider:

  1. Central nervous system (CNS) depressants—Medications like benzodiazepines, opioids, sleeping pills, and certain antidepressants can amplify the sedative effects of cyclobenzaprine. This increased sedation can lead to excessive drowsiness, dizziness, and impaired cognitive and motor functions
  2. Monoamine oxidase inhibitors (MAOIs)—Combining cyclobenzaprine with MAOIs or taking cyclobenzaprine within 14 days of discontinuing an MAOI can lead to serious interactions, including hypertensive crisis and serotonin syndrome
  3. Anticholinergic drugs—Medications with anticholinergic properties (such as some antihistamines, tricyclic antidepressants, and certain medications for Parkinson's disease) can enhance the anticholinergic side effects of cyclobenzaprine, like dry mouth, urinary retention, and constipation
  4. Blood pressure medications—Cyclobenzaprine can enhance the blood pressure-lowering effects of some antihypertensive drugs, potentially leading to hypotension (low blood pressure)
  5. CYP1A2 inhibitors—Drugs that inhibit the CYP1A2 enzyme can slow down the metabolism of cyclobenzaprine, increasing its concentration and potentially leading to more pronounced side effects
  6. Over-the-counter medications and supplements—Certain over-the-counter drugs and herbal supplements may also interact with cyclobenzaprine. For example, over-the-counter sleep aids, cold and allergy medications, and herbal supplements can interfere with cyclobenzaprine’s effects and vice versa

Source: Kampus Production

Cyclobenzaprine—Important Disclaimers

If you’re planning on using cyclobenzaprine, keep in mind these additional precautions and disclaimers:

  • Cyclobenzaprine is available only with a doctor's prescription. You should use it exactly as prescribed, in the dosage advised by your healthcare provider
  • Although cyclobenzaprine isn’t classified as a controlled drug by the FDA, you shouldn’t use it for a prolonged period. Typically, the treatment period is limited to two to three weeks
  • Avoid taking cyclobenzaprine if you have conditions like hyperthyroidism, heart block, congestive heart failure, or after a recent heart attack
  • While less common, there’s a potential for addiction and abuse with cyclobenzaprine, especially with prolonged use or in higher doses
  • As with any medication, there’s a risk of allergic reactions. Seek immediate medical attention if you experience symptoms like difficulty breathing, swelling, or severe rashes
  • In some cases, suddenly stopping the medication after prolonged use can lead to withdrawal symptoms

Featured image source: Gustavo Fring