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Can You Take Cyclobenzaprine and Gabapentin Together? A Practical Guide

Can You Take Cyclobenzaprine and Gabapentin Together? A Practical Guide

After enjoying a restful night’s sleep, you wake up feeling prepared to face the day’s challenges. However, ensuring you get an adequate amount of sleep isn’t always easy—some nights, you might find yourself tossing and turning despite feeling exhausted. In such situations, sleep medications like cyclobenzaprine and gabapentin can be invaluable in helping you rejuvenate for the day ahead.

While both medications have demonstrated their efficacy in resolving sleep issues when considering using these drugs, you might wonder—is it okay to take gabapentin and cyclobenzaprine together? To give you peace of mind, we’ll explore the potential interactions between gabapentin and cyclobenzaprine, providing insights into their compatibility.

Cyclobenzaprine vs. Gabapentin— An Overview

Cyclobenzaprine, sold under the brand name Flexeril, among others, is an FDA-approved centrally acting muscle relaxant, which works by blocking the transmission of pain signals from the nerves to the brain, helping relax your muscles. Cyclobenzaprine is commonly used to treat muscle spasms associated with acute musculoskeletal conditions, such as:

It also has sedative effects, which can be helpful if you’re struggling with insomnia. Doctors commonly prescribe cyclobenzaprine for short-term use, typically up to two to three weeks.

Meanwhile, gabapentin was initially developed as a muscle relaxant and anti-spasmodic medication. It later proved effective as an anticonvulsant drug for seizure prevention, both when used independently and in combination with stronger anticonvulsants. Gabapentin is approved for treating issues like moderate-to-severe restless legs syndrome (RLS), but its calming effect also makes it beneficial for insomnia treatment. It’s used off-label for treating:

  • Neuropathic pain
  • Fibromyalgia
  • Bipolar disorder
  • Essential tremors
  • Anxiety
  • Irritable bowel syndrome (IBS)
  • Alcohol withdrawal
  • Nausea and vomiting
  • Headache
  • Generalized tonic-clonic seizures
  • Pruritus (itching)

Gabapentin works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain and spinal cord. GABA is a neurotransmitter that plays a role in regulating nerve activity. By increasing GABA levels, gabapentin reduces the excitability of nerve cells, which helps prevent seizures, relieve pain, and promote relaxation.

Image source: Kinga Howard

Gabapentin  vs. Cyclobenzaprine—Key Facts

You can learn some key facts about cyclobenzaprine and gabapentin in the following table:




Drug class

Skeletal muscle relaxant

Anticonvulsant/skeletal muscle relaxant

Brand names

Flexeril, Amrix, FusePaq, Fexmid, and Tramadol

Fanatrex, Gabarone, Gralise, and Neurontin

FDA classification

Not a controlled drug

Not a controlled drug




Available dosages

5 mg, 10 mg, 15 mg, and 30 mg

100 mg, 300 mg, 400 mg, 600 mg, 900 mg, 1800 mg

Dosage form(s) available

Oral capsule/tablet

Oral capsule/solution/tablet

Suitable for children



Suitable for pregnant women

Category B (no proven risk in pregnancy)

Category C (risk cannot be ruled out)


With food

With or without food

Side effects



Cyclobenzaprine vs. Gabapentin—Dosage and Administration

Gabapentin and cyclobenzaprine are both muscle relaxers, but they work in different ways with specific dosages and administration instructions.

Cyclobenzaprine is available in immediate-release tablets and extended-release tablets. For adults, the recommended dosage for immediate-release tablets is 5 mg to 10 mg, taken three times a day, while that of extended-release tablets is 10 mg to 20 mg, taken once a day. You should take cyclobenzaprine with food to reduce the risk of stomach upsets.

Gabapentin is available in capsules, solutions, and tablets. The recommended dosage of capsules for adults is 300 mg to 900 mg, taken three times a day, while the usual dosage for tablets is 600 mg to 1800 mg, taken three times a day. As opposed to cyclobenzaprine, you can take gabapentin with or without food.

Here are all the available dosages for cyclobenzaprine and gabapentin:



  • 5 mg

  • 10 mg

  • 15 mg

  • 30 mg

  • 100 mg

  • 300 mg

  • 400 mg

  • 600 mg

  • 900 mg

  • 1800 mg

These are general guidelines—your specific dosage and administration instructions for cyclobenzaprine and gabapentin will vary depending on your condition and medical history. You should always talk to your doctor about the best way to take these medications.

Can Gabapentin and Cyclobenzaprine Be Taken Together?

While it’s not strictly forbidden to take gabapentin and cyclobenzaprine together, both medications have the potential to induce drowsiness and sedation. Mixing these drugs may exacerbate undesired effects, increasing the likelihood of drowsiness, dizziness, and impaired coordination. Both medications can cause respiratory depression, especially when taken in high doses or with other central nervous system depressants such as opioids or benzodiazepines.

Before combining cyclobenzaprine with gabapentin, talk to your doctor. They can evaluate your particular situation and determine whether the potential benefits outweigh the risks. They can adjust the dosages, suggest alternative medications, or offer instructions for safe use.

Which Pain Medicine Is Better, Cyclobenzaprine or Gabapentin?

When choosing between cyclobenzaprine and gabapentin, it’s essential to consider your specific condition and medical history. If you’re experiencing pain primarily caused by muscle spasms, cyclobenzaprine is often the preferred choice because it directly relaxes your muscles. In case you’re experiencing nerve pain, gabapentin is generally considered more effective due to its ability to modulate nerve activity and reduce pain associated with nerve damage.

Besides treating muscle and nerve pain, gabapentin and cyclobenzaprine have sedative properties, so they can make you feel drowsy and relaxed. This can be helpful if you’re having trouble falling or staying asleep. While these medications offer an effective solution for managing your sleep issues, seeking guidance from a sleep specialist is essential to ensure the most suitable approach for your specific needs. Seeing such experts can be a daunting task, as only about 1% of doctors in the U.S. specialize in sleep medicine. Fortunately, online performance medicine clinics like Kick offer a convenient solution to this problem.

Kick—Sleep Solutions Designed by Experts

Designed by a Stanford sleep expert, Dr. Alex Dimitriu, Kick’s all-encompassing sleep program offers an efficient solution to sleeplessness. To get started, all you need to do is fill out a brief questionnaire with relevant information about your current sleep concerns and medical history. 

Within 24 hours, our sleep doctor will assess your condition and create a personalized treatment plan. They’ll prescribe two different sleep medications, allowing you to determine the most effective option quickly. You can choose to have the medications delivered to your local pharmacy or directly to your home.

Our off-label sleep medications will help you fall asleep easily and experience restful nights more consistently. You’ll be able to try the following medications depending on your condition:

  1. Trazodone
  2. Hydroxyzine
  3. Cyclobenzaprine
  4. Ramelteon
  5. Gabapentin
  6. Doxepin (coming soon)

If you still find yourself struggling with sleep after initiating your treatment plan, don’t hesitate to inform our sleep doctor—they’ll evaluate your situation and make necessary adjustments to your treatment to achieve the desired results. They’ll also schedule regular check-ins and provide cognitive behavioral therapy for insomnia (CBT-I) coaching to improve your sleep habits and overall sleep quality.

Get Started With Kick Today

Image source: Ketut Subiyanto

Our dedication to helping our clients achieve better sleep is evident in the glowing user reviews on Trustpilot. To become a part of the better sleep club, all you need to do is:

  1. Sign up and start your 15-minute sleep consultation
  2. Complete a questionnaire to help us understand your current situation and medical history
  3. Provide your shipping and billing information

If our doctor determines that Kick isn’t the best fit for you after reviewing the information you’ve provided, you won’t be charged for the initial consultation, as per our Doctor Guarantee policy.

Embrace the power of peaceful sleep and bid farewell to sleepless nights with Kick’s effective sleep solutions!

Gabapentin  vs. Cyclobenzaprine—Potential Side Effects

Image source: Yuris Alhumaydy

When considering the use of gabapentin and cyclobenzaprine, it’s important to be mindful of the potential side effects linked to these medications. While these medications have distinct mechanisms of action, they can induce similar side effects, including:

  • Drowsiness
  • Cold or flu-like symptoms
  • Constipation
  • Dizziness
  • Blurred vision
  • Double vision
  • Eye pain
  • Fatigue
  • Headache
  • Dry mouth
  • Coordination problems
  • Sweating
  • Weight gain

It’s crucial for patients to report any unusual or severe side effects to their healthcare provider promptly. Additionally, sudden discontinuation of medications, especially gabapentin, should be done under medical supervision to prevent withdrawal symptoms.

Cyclobenzaprine vs. Gabapentin—Important Disclaimers

While both medications are effective in treating certain conditions, there are a few key things to keep in mind:

  1. Both gabapentin and cyclobenzaprine can interact with other medications, so you must tell your doctor about all the medications you’re taking in advance to ensure your safety
  2. Alcohol may intensify the side effects of these medications, which is why you should avoid alcohol consumption during your treatment
  3. Neither cyclobenzaprine nor gabapentin is recommended if you’re pregnant or breastfeeding due to potential risks
  4. Adhere to the prescribed doses and administration instructions from your healthcare provider. Altering the dosage without medical guidance can lead to adverse effects, including addiction
  5. Both medications may cause drowsiness and dizziness. Be careful when driving or operating heavy machinery and refrain from such demanding activities until you understand how the medication affects you
  6. While rare, both medications have the potential to cause weight gain, so it’s important to monitor your weight and talk to your doctor if you notice any significant changes

These precautions highlight the importance of informed and responsible medication use. You should actively engage with your healthcare provider to ensure the safe and effective use of cyclobenzaprine and gabapentin based on your unique health circumstances.

Featured image source: alan KO